Post-doctorate at Karolinska Medical College, Sweden, Member of the Laboratory Diagnostics Group of the Chinese Medical Association Chinese Society of Hematology, member of the Hematology Group of the Hematology Branch of the Chinese Anti-Cancer Association. Review expert of National Natural Science Foundation of China, Provincial Fund and Ministry of Education Study Abroad Fund. Mainly engaged in the clinical diagnosis and basic research of hematological diseases. The quantitative detection of leukemia fusion genes and the fluorescent in situ hybridization (FISH) detection of leukemia were carried out earlier in China and in the province, and obtained international certification. Professor Ma is good at molecular diagnosis, stratified diagnosis of hematology disease and individualized diagnosis and treatment. He has undertook 6 National Natural Science Foundation projects, 4 provincial and ministerial projects, and published more than 40 SCI papers as a correspondence or first author, with accumulative impact factor of more than 90, and won multiple awards such as the Ministry of Education and Shandong Science and Technology Progress Award. Projects are listed as followed:

1. National Natural Science Foundation of China，The effects and mechanisms of imbalanced bone marrow Th immunological network regulated by gut microbiota via “gut-bone marrow axis” in acute myeloid leukemia under the framework of systems biology.

2. National Natural Science Foundation of China, The effects and mechanisms of imbalanced Th immunological network regulated by bone marrow sympathetic nerve in acute myeloid leukemia under the framework of systems biology.

3. National Natural Science Foundation of China, The effects and mechanisms of NLRP3 inflammasome-mediated Th subsets imbalance in acute myeloid leukemia. 

4. National Natural Science Foundation of China, The study on regulatory network modelling and key pathways of Th subsets cytokines in bone marrow microenvironment of the patients with acute myeloid leukemia. 

5. National Natural Science Foundation of China, The role and mechanism of Notch pathway in Th17/Treg imbalance of ITP. 

6. Department of Science & Technology of Shandong province, Study on the effect and mechanism of intervention of Notch pathway on reversing Th17/Treg imbalance in patients with ITP.

7. Department of Science & Technology of Shandong province, The Role and Mechanism of Delta4/Notch and VEGF Feedback Loop in Lung Cancer Tumor Angiogenesis.

8. National Natural Science Foundation of China, Preparation of HLA-specific HCMV Tandem Epitope Vaccine and Study on Immune Effect in Chinese Population. 

9. Department of Science & Technology of Shandong province, Study of HLA-specific HCMV combined with nucleic acid epitope vaccine and its immune effect in Chinese population

10. Department of Science & Technology of Shandong province, Mechanisms of Sympathetic Transmitter System Mediated Th Subgroup and NLRP3 Inflammatory Immune Disorders in Bone Marrow Microenvironment in Acute Myeloid Leukemia.

Paper are listed as followed:

(1). Jingbo Zhang, Daoxin Ma*, Xiaojuan Zhu, Xun Qu, Chunyan Ji, Ming Hou. Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura. Haematologica. 2009 Sep; 94(9) :1326-1329  

(2). Zhu Xiaojuan, *Ma Daoxin, Zhang Jingbo, Peng Jun, Qu Xun, Ji Chunyan, Hou Ming. Elevated Interleukin-21 Correlated to Th17 and Th1 Cells in Patients with Immune Thrombocytopenia. J Clin Immunol. 2010 Mar;30(2):253-9.

(3). Ma Daoxin*, Zhu Xiaojuan, Zhao Ping, Zhao Chunhong, Li Xiaofang, Zhu Yuanyuan, Li Lizhen, Sun Jianzhi, Peng Jun, Ji Chunyan, Hou Ming. Profile of Th17 cytokines (IL-17, TGF-beta, IL-6) and Th1 cytokine (IFN-gamma) in patients with immune thrombocytopenic purpura. Ann Hematol. 2008 Nov;87(11):899-904.

(4). Ma Daoxin*, Dai Jianjian, Zhu Xiaojuan, Yan Shuxin, Zhao Ping, Zhang Jian, Zhu Yuanuan, Sun Jianzhi, Peng Jun, Ji Chunyan, Hou Ming. Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura. Ann Hematol. 2010 Feb;89(2):155-161.

(5). Ping Zhao, Daoxin Ma*, Fuzhong Xue,Chunyan Ji, Shukang Wang, Xiaomei Zhang, Yabin Zhou, Xiuping Yu. Seroprevalence and risk factors of human cytomegalovirus infection in the eastern Chinese population. Arch Virol. 2009 Apr;154(4):561-564.

(6). Ping Zhao, Daoxin Ma*, Shuxin Yan, Na Shao, Jingru Zhang, Zheng Bi, Jianjian Dai, Min Ji, Chunyan Ji. Towards a novel vaccine against human cytomegalovirus based on a chimeric Ad5F35 adenovirus vector expressing the immunodominant antigenic domain 1 epitope. Intervirology. 2009;52(1):35-42.

(7).  Ma Daoxin*, Zhu Yuanchao, Ji Chunyan, Hou Ming. Targeting the Notch signaling pathway in autoimmune diseases.Expert Opin Ther Targets. 2010 Oct;14(5):553-565.

(8). Zhang Lei, Li Jianmin, Liu Xinguang, Ma Daoxin*, Hu Naiwen, Li Yonggang, Li Wei, Hu Yu, Yu Shuang, Qu Xun, Yang Meixiang, Feng Alei, Wang Guanghui. Elevated th22 cells correlated with th17 cells in patients with rheumatoid arthritis. J Clin Immunol. 2011 Aug;31(4):606-14. Epub 2011 May 10.

(9). Hu Yu, Ma Daoxin*, Shan Ningning, Zhu Yuanyuan, Liu Xinguang, Zhang Lei, Yu Shuang, Ji Chunyan, Hou Ming. Increased Number of Tc17 and Correlation with Th17 Cells in Patients with Immune Thrombocytopenia. PLoS One. 2011 Oct;6(10):e26522. Epub 2011 Oct 24.

(10). Zhao Ping, Ma Daoxin*, Yu Shuang, Xue Fuzhong, Zhu Weiwei, Shao Na, Zhang Jingru, Ji Chunyan*. The development of Chinese specific human cytomegalovirus polyepitope recombinant vaccine. Antiviral Res. 2012 Feb;93(2):260-9. Epub 2011 Dec 13.

(11). Lei Zhang, Yong-gang Li, Yu-hua Li, Lei Qi, Xin-guang Liu, Cun-zhong Yuan, Nai-wen Hu, Daoxin Ma*, Zhen-feng Li, Qiang Yang, Wei Li, Jian-min Li*. Increased Frequencies of Th22 Cells as well as Th17 Cells in the Peripheral Blood of Patients with Ankylosing Spondylitis and Rheumatoid Arthritis. PLoS One. 2012 Apr; 7(4): e31000.

(12). Hu Yu, Li Haiyan, Zhang Lei, Shan Baozhong, Xu Xingfang, Li Hong, Liu Xinguang, Xu Shuqian, Yu Shuang, Ma Daoxin*, Peng Jun, Hou Ming. Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia. Hum Immunol. 2012 Jun;73(6):629-35. Epub 2012 Apr 23.

(13). Lin-lin Shao, Lei Zhang, Yu Hou, Shuang Yu, Xin-guang Liu, Xiao-yang Huang, Yuan-xin Sun, Tian Tian, Na He, Dao-xin Ma*, Jun Peng, Ming Hou. Th22 Cells as Well as Th17 Cells Expand Differentially in Patients with Early-Stage and Late-Stage Myelodysplastic Syndrome. PLoS One. 2012 Dec;7(12):e51339. doi:10.1371/journal.pone.0051339. Epub 2012 Dec 7.

(14). Yu S, Sun J, Zhang J, Xu X, Li H, Shan B, Tian T, Wang H, Ma D*, Ji C. Aberrant expression and association of VEGF and Dll4/Notch pathway molecules under hypoxia in patients with lung cancer. Histol Histopathol. 2013 Feb;28(2):277-84.

(15). Tian Tian, Sun Yuanxin, Li Meng, He Na, Yuan Cunzhong, Yu Shuang, Wang Min, Ji Chunyan, Ma Daoxin*. Increased Th22 cells as well as Th17 cells in patients with adult T-cell acute lymphoblastic leukemia. Clin Chim Acta. 2013 Nov 15;426:108-13. doi: 10.1016/j.cca.2013.09.014. Epub 2013 Sep 21.

(16). Tian Tian, Yu Shuang, Wang Min, Yuan Cunzhong, Zhang Hua, Ji Chunyan, Ma Daoxin. Aberrant T helper 17 cells and related cytokines in bone marrow microenvironment of patients with acute myeloid leukemia. Clin Dev Immunol. 2013;2013:915873. doi: 10.1155/2013/915873. Epub 2013 Aug 18.

(17). Wang Min#, Tian Tian, Yu Shuang, He Na, Ma Daoxin*. Th17 and Treg Cells in Bone Related Diseases. Clinical and Developmental Immunology, 2013;2013:203705.

(18). Tian T, Yu S, Ma D. Th22 and related cytokines in inflammatory and autoimmune diseases. Expert Opin Ther Targets. 2013 Feb;17(2):113-25  

(19).Shuang Yu,Chuanfang Liu,Lei Zhang,Baozhong Shan,Tian Tian,Yu Hu,Linlin Shao,Yuanxin Sun,Chunyan Ji, Daoxin Ma*.Elevated Th22 Cells Correlated with Th17Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia. Int. J. Mol. Sci.2014, 15(2), 1927-1945

(20).Wang M, He N, Tian T, Liu L, Yu S, Ma D. Mutation Analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese Patients with Myeloproliferative Neoplasms.

 Biomed Res Int. 2014;2014:485645. doi: 10.1155/2014/485645. Epub 2014 May 11.

(21). Sun YX, Kong HL, Liu CF, Yu S, Tian T, Ma DX, Ji CY. The imbalanced profile and clinical significance of T helper associated cytokines in bone marrow microenvironment of the patients with acute myeloid leukemia. Hum Immunol. 2014 Feb;75(2):113-8. doi: 10.1016/j.humimm.2013.11.014. Epub 2013 Nov 20.

(22).Wang Min#, Chen Ping#, Jia Yan, He Na, Li Daqi, Ji Chunyan, Ma Daoxin*. Elevated Th22 as well as Th17 cells associated with therapeutic outcome and clinical stage are potential targets in patients with multiple myeloma. Oncotarget. 2015 Jul 20;6(20):17958-67.

(23). Tian T, Yu S, Liu L, Xue F, Yuan C, Wang M, Ji C, Ma D. The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations. PLoS One. 2015 Jul 2;10(7):e0131761.

(24). Chen Ping#, Wang Min#, Li Daqi, Jia Yan, He Na, Li Wei, Ma Daoxin*, Ji Chunyan. The alteration and clinical significance of Th22/Th17/Th1 cells in patients with chronic myeloid leukemia. J Immunol Res. 2015;2015:416123.

(25). Hu Yu, Wang Xiuwen, Yu Shuang, Hou Yu, Ma Daoxin, Hou Ming. Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia. Expert Opin Ther Targets. 2015 Jun;19(6):723-32.

(26) Chen Chen, Liu Yan, Hua Mingqiang, Li Xiaomei, Ji Chunyan, Ma Daoxin. Neuropathy correlated with imbalanced Foxp3/IL-17 in bone marrow microenvironment of patients with acute myeloid leukemia. Oncotarget. 2016 Apr 26;7(17):24455-65.

(27). Liu Lu, Hua Ming, Liu Chuanfang, He Na, Li Zhao, Ma Daoxin. The aberrant expression of microRNAs and correlations with T cell subsets in patients with immune thrombocytopenia. Oncotarget. 2016 Nov 22;7(47):76453-76463. doi: 10.18632/oncotarget.12949.

(28) Yin Congcong, He Na, Li Peng, Zhang Chen, Yu Jie, Hua Mingqiang, Ji Chunyan, Ma Daoxin. Polymorphisms of Interlukin-1β rs16944 confer susceptibility to myelodysplastic syndromes. Life Sci. 2016 Nov 15;165:109-112.

(29) Wang Jingyi, Hao Jianguo, He Na, Ji Chunyan, Ma Daoxin. The Mutation Profile of Calreticulin in Patients with Myeloproliferative Neoplasms and Acute Leukemia. Turk J Haematol. 2016 Sep 5;33(3):180-6.

(30 )Wang Hong, Hua Mingqiang, Wang Shukang, Yu Jie, Chen Chen, Zhao Xueyun, Zhang Chen, Zhong Chaoqin, Wang Ruiqing, He Na, Hou Ming, Ma Daoxin. Genetic polymorphisms of IL-18 rs1946518 and IL-1β rs16944 are associated with prognosis and survival of acute myeloid leukemia. Inflamm Res. 2017 Mar;66(3):249-258

(31) Wang R, Zhong C, Zhang C, Hua M, Ma D. Insight to Pharmacokinetics of TKIs: Optimizing Practical Guidelines for Individualized Therapy. Curr Drug Metab.2017;18(3):199-206

(32)  Yu Shuang, Liu Chuanfang, Li Lanhua, Tian Tian, Wang Min, Hu Yu, Yuan Cunzhong, Zhang Lei, Ji Chunyan, Ma Daoxin*. Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia. Lab Invest. 2015 Feb;95(2):157-67.

(33). Li W, Zhong C, Jiao J, Li P, Cui B, Ji C, Ma D. Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. Int J Mol Sci. 2017 Mar 9;18(3). pii: E597. doi: 10.3390/ijms18030597.

(34). Yu J, Hua M, Zhao X, Wang R, Zhong C, Zhang C, Wang R, Li G, He N, Hou M, Ma D. NF-κB-94ins/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia. J Immunol Res. 2018 Jul 22;2018:8170436. doi: 10.1155/2018/8170436.

(35). Wang M, Zhang C, Tian T, Zhang T, Wang R, Han F, Zhong C, Hua M, Ma D. Increased Regulatory T Cells in Peripheral Blood of Acute Myeloid Leukemia Patients Rely on Tumor Necrosis Factor (TNF)-α-TNF Receptor-2 Pathway. Front Immunol. 2018 Jun 5;9:1274. doi: 10.3389/fimmu.2018.01274

(36). Zhang J, Wang Y, Wang J, Hu J, Chen S, Jin J, Liu T, Zhou J, Hu Y, Ma D, Huang X, Ji C, Hou M. Early BCR-ABL1 decline in imatinib-treated patients with chronic myeloid leukemia: results from a multicenter study of the Chinese CML alliance. Blood Cancer J. 2018 Jun 15;8(7):61. doi: 10.1038/s41408-018-0093-4.

(37). Zhang C, Han F, Yu J, Hu X, Hua M, Zhong C, Wang R, Zhao X, Shi Y, Ji C, Ma D. Investigation of NF-κB-94ins/del ATTG and CARD8 (rs2043211) Gene Polymorphism in Acute Lymphoblastic Leukemia. Front Endocrinol (Lausanne). 2019 Aug 2;10:501. doi: 10.3389/fendo.2019.00501. eCollection 2019.

(38). Wang Jingyi#, He Na#, Wang Ruiqing#, Tian Tian, Han Fengjiao, Zhong Chaoqin, Zhang Chen, Hua Mingqiang, Ji Chunyan, Ma Daoxin*. Analysis of TET2 and EZH2 gene functions in chromosome instability in acute myeloid leukemia. Sci Rep. 2020 Feb 17;10(1):2706.

(39). Ma Daoxin, Rudd E, Edner J, Gavhed S, Ramme KG, Fadeel B, Nordenskjöld M, Henter JI, Zheng C. Sequence analysis of the SRGN, AP3B1, ARF6, and SH2D1A genes in familial hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008 May;50(5):1067-1069

(40). Ma Daoxin, Dong Xuebin, Zang Shaolei, Ma Rong, Zhao Ping, Guo Dongmei, Dai Jianjian, Chen Feng, Ye Jingjing, Ji Chunyan. Aberrant expression and clinical correlation of Notch signaling molecules in breast cancer of Chinese population. Asia Pac J Clin Oncol. 2011 Dec;7(4):385-91.

(41). Fang Y, Yu S, Ma Y, Sun P, Ma D, Ji C, Kong B. Association of Dll4/Notch and HIF-1a -VEGF Signaling in the Angiogenesis of Missed Abortion. PLoS One. 2013;8(8):e70667. doi: 10.1371/journal.pone.0070667.

(42). Zhang Shouting, Ma Daoxin, Wang Xiangling, Celkan T, Nordenskjöld M, Henter JI, Fadeel B, Zheng C. Syntaxin-11 is expressed in primary human monocytes/macrophages and acts as a negative regulator of macrophage engulfment of apoptotic cells and IgG-opsonized target cells. Br J Haematol. 2008 Jul;142(3):469-479.

(43). Dai Jianjian, Ma Daoxin, Zang Shaolei, Guo Dongmei, Qu Xun, Ye Jingjing, Ji Chunyan. Cross-Talk Between Notch and EGFR Signaling in Human Breast Cancer Cells. Cancer Invest. 2009;27(5):533-540.

(44). Shuxin Yan, Daoxin Ma, Min Ji, Dongmei Guo, Jianjian Dai, Ping Zhao, Chunyan Ji. Expression profile of Notch-related genes in multi-drug resistant K562/A02 cells compared with parental K562 cells. Int J Lab Hematol. 2010;32(2):150-158

(45) Zhang J, Ma D, Ye J, Zang S, Lu F, Yang M, Qu X, Sun X, Ji C. Prognostic impact of delta-like ligand 4 and Notch1 in acute myeloid leukemia. Oncol Rep. 2012 Oct;28(4):1503-11. doi: 10.3892/or.2012.1943. Epub 2012 Jul 31.

(46). Huang Xiangnan#, Ma Daoxin#, Dong Wenhao, Li Peng, Lu Ting, He Na, Tian Tian, Liu Na, Du Yahui, Ji Chunyan. Gene expression profiling of the DNMT3A R882 mutation in acute leukemia. Oncol Lett. 2013 July; 6(1): 268–274.

(47). Ting Lu, Shuang Yu, Yan Liu, Congcong Yin, Jingjing Ye, Zhi Liu, Daoxin Ma*, Chunyan Ji1*. Aberrant Circulating Th17 Cells in Patients with B-Cell Non-Hodgkin’s Lymphoma. PLoS One. 2016 Jan 26;11(1):e0148044.

(48). Lu T, Liu Y, Li P, Yu S, Huang X, Ma D, Ji C. Decreased circulating Th22 and Th17 cells in patients with aplastic anemia. Clin Chim Acta. 2015 Oct 23;450:90-6.