08/83 - 08/86    Master Degree of Medicine, Pathology

Shandong Medical University, Jinan, China

08/73 - 12/77    Medical Degree

Shandong Medical School, Jinan, China

02/83 – 07/83    Intensive English training in Beijing Second foreign language Institute

 

 

12/06. The University Scientific Research Achievement Award (first class) for “research on the reversal effect of ribozyme and interference RNA on breast cancer multidrug resistance” by Shandong Provincial Education Department. 

11/03. The Science and Technology Progress Award for “research on expression of tumor drug resistance-related genes and the reversal effect of plant polyphenols on the genes”  by Department of Science &Technology of Shandong Province.

 

11/97. Visiting professor to Wakayama Medical College of Japan as a member of delegation of Shandong Medical University. Presented“Function and classification of human pituitary adenoma”in English.

10/95. Academic awards for clinical study of pathology on IgA nephropathy by Science Commission of Shandong Province.

08/95. Committee member, Chinese Pathology Association.
      Chairman, Shandong Branch of Chinese Pathological Association.
      Academic award for immunohistochemical study on pituitary adenoma by Science Commission of Shandong Division.

Director of National Clinical Key Subject of Pathology

Director of Program of "Bilingual Education Model Curriculum”

Former Chairman of Institute of Pathology & Pathophysiology

Professor of Pathology

Former Standing Committee of Chinese Academy of Pathology

Former Chairman of Shandong Academy of Pathology

Reviewer of English Edition of Chinese Journal of Medicine

 

Subsidy given by State Department

1. The Third Class Medal of Shandong Science Committee, 1994

2. The Third Class Medal of Shandong Science Committee, 1995

3. The First Class Medal of Shandong Health Department, 1999

4. The Third Class Medal of Science Improvement of Shandong Science Department, 2003

5. The Third Class Medal of Science Improvement of Shandong Science Department, 2008

6 Outstanding pathologist, Chinese American Pathologists  Association 2013

7 Qilu Famous doctor of the first session

 

<Molecular Pathology>, <Pathology> and <Experiment of Pathology

 

Xuanxuan Jing*, Hui Zhang*, Jing Hu, Peng Su, Wei Zhang, Ming Jia, Hongxia Cheng, Weiwei Li, Gengyin Zhou.β-arrestin 2 is associated with multidrug resistance in breast cancer cells through regulating MDR1 gene expression. International Journal of Clinical and Experimental Pathology. 2015;8(2):1354-1363.

Hui Zhang*, Xuanxuan Jing*, Xiaojuan Wu, Jing Hu, Xiaofang Zhang,Xiao Wang, Peng Su, Weiwei Li and Gengyin Zhou.Suppression of multidrug resistance by rosiglitazone treatment in human ovarian cancer cells through downregulation of FZD1 and MDR1 genes. Anti-cancer Drugs. 2015. 

Sun Y, Nakanishi M, Sato F, Oikawa K, Muragaki Y, Zhou G. Biochem Biophys Res Commun.Trps1 deficiency inhibits the morphogenesis of secondary hair follicles via decreased Noggin expression. 2015 Jan 16;456(3):721-6.

Su P, Hu J, Zhang H, Jia M, Li W, Jing X, Zhou G: Association of TRPS1 gene with different EMT markers in ERalpha-positive and ERalpha-negative breast cancer. Diagn Pathol 2014, 9:119.

Hu J, Su P, Jia M, Wu X, Zhang H, Li W, Zhou G: TRPS1 expression promotes angiogenesis and affects VEGFA expression in breast cancer. Exp Biol Med (Maywood) 2014, 239(4):423-429.

Jia M, Hu J, Li W, Su P, Zhang H, Zhang X, Zhou G: Trps1 is associated with the multidrug resistance of osteosarcoma by regulating MDR1 gene expression. FEBS Lett 2014, 588(5):801-810.

Li W, Jia M, Qin X, Hu J, Zhang X, Zhou G: Harmful effect of ERbeta on BCRP-mediated drug resistance and cell proliferation in ERalpha/PR-negative breast cancer. FEBS J 2013, 280(23):6128-6140.

Wu X, Zhang X, Sun L, Zhang H, Li L, Wang X, Li W, Su P, Hu J, Gao P, Zhou G: Progesterone negatively regulates BCRP in progesterone receptor-positive human breast cancer cells. Cell Physiol Biochem 2013, 32(2):344-354.

Cheng H, Qin Y, Fan H, Su P, Zhang X, Zhang H, Zhou G: Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes. Diagn Pathol 2013, 8:129.

Xiang L, Zhou G, Su P, Xia S, Han B, Wang Y, Zhang T: Could postmortem hemorrhage occur in the brain?: a preliminary study on the establishment and investigation of postmortem hypostatic hemorrhage using rabbit models. Am J Forensic Med Pathol 2013, 34(2):147-149.

Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G: The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling. Dev Biol 2013, 377(2):415-427.

Gao P, Xing AY, Zhou GY, Zhang TG, Zhang JP, Gao C, Li H, Shi DB: The molecular mechanism of microRNA-145 to suppress invasion-metastasis cascade in gastric cancer. Oncogene 2013, 32(4):491-501.

Zhang X, Li HM, Liu Z, Zhou G, Zhang Q, Zhang T, Zhang J, Zhang C: Loss of heterozygosity and methylation of multiple tumor suppressor genes on chromosome 3 in hepatocellular carcinoma. J Gastroenterol 2013, 48(1):132-143.

Zhang X, Wu X, Su P, Gao Y, Meng B, Sun Y, Li L, Zhou Z, Zhou G: Doxorubicin influences the expression of glucosylceramide synthase in invasive ductal breast cancer. PLoS One 2012, 7(11):e48492.

Yang X, Zhou G, Ren T, Li H, Zhang Y, Yin D, Qian H, Li Q. β-Arrestin prevents cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt pathways.Apoptosis. 2012 Sep;17(9):1019-26

Gui T, Zhou G, Sun Y, Shimokado A, Itoh S, Oikawa K, Muragaki Y. MicroRNAs that target Ca(2+) transporters are involved in vascular smooth muscle cell calcification. Lab Invest. 2012 Sep;92(9):1250-9. doi: 10.1038/labinvest.2012.85. Epub 2012 Jun 11.

Xiang L, Liu ZH, Huan Q, Su P, Du GJ, Wang Y, Gao P, Zhou GY. Hypoxia-inducible factor-2a is associated with ABCG2 expression, histology-grade and Ki67 expression in breast invasive ductal carcinoma. Diagn Pathol. 2012 Mar 27;7:32.

Li Y, Zhou G, Ozaki T, Nishihara E, Matsuzuka F, Bai Y, Liu Z, Taniguchi E, Miyauchi A, Kakudo K: Distinct histopathological features of Hashimoto's thyroiditis with respect to IgG4-related disease. Mod Pathol 2012, 25(8):1086-1097.

Zhang H, Zhang X, Wu X, Li W, Su P, Cheng H, Xiang L, Gao P, Zhou G. Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway. Cancer Lett. 2012 Oct 1;323(1):106-13. Epub 2012 Apr 4.

Wu X, Zhang X, Zhang H, Su P, Li W, Li L, Wang Y, Liu W, Gao P, Zhou G: Progesterone Receptor Down-Regulates BCRP Expression via Binding to the Progesterone Response Element in Breast Cancer. Cancer Sci 2012, 103 (5):959-967.

Gao P, Wei JM, Li PY, Zhang CJ, Jian WC, Zhang YH, Xing AY, Zhou GY. Screening of deoxyribozyme with high reversal efficiency against multidrug resistance in breast carcinoma cells. J Cell Mol Med. 2011 Oct;15(10):2130-8.

Mu K, Li L, Yang Q, Zhang T, Gao P, Meng B, Liu Z, Wang Y, Zhou G. Detection of CHK1 and CCND1 gene copy number changes in breast cancer with dual-colour fluorescence in-situ hybridization. Histopathology. 2011 Mar;58(4):601-7.

Liu J, Wang X, Zhou G, Wang H, Xiang L, Cheng Y, Liu W, Wang Y, Jia J, Zhao W: Cancerous inhibitor of protein phosphatase 2A is overexpressed in cervical cancer and upregulated by human papillomavirus 16 E7 oncoprotein. Gynecol Oncol 2011, 122(2):430-436.

Liu Z, Zhou G, Nakamura M, Koike E, Li Y, Ozaki T, Mori I, Taniguchi E, Kakudo K. Encapsulated follicular thyroid tumor with equivocal nuclear changes, so-called well-differentiated tumor of uncertain malignant potential: a morphological, immunohistochemical, and molecular appraisal. Cancer Sci. 2011 Jan; 102(1):288-94.

Zhang X, Wu X, Li J, Sun Y, Gao P, Zhang C, Zhang H, Zhou G. MDR1 (multidrug resistence 1) can regulate GCS (glucosylceramide synthase) in breast cancer cells. J Surg Oncol. 2011 Oct;104(5):466-71.

Zeng Q, Liu H, Zhang K, Li C and Zhou G. Noninvasive evaluation of cerebral glioma grade by using multivoxel 3D proton MR spectroscopy. Magn Reson Imaging. 2011 Jan; 29(1):25-31.
Xiang L, Su P, Xia S, Liu Z, Wang Y, Gao P, Zhou G. ABCG2 is associated with HER-2 expression, lymph node metastasis and clinical stage in breast invasive ductal carcinoma. Diagn Pathol. 2011 Sep 27;6:90.

Liu Z, Zhou G, Nakamura M, Bai Y, Li Y, Ozaki T, Mori I, Miyauchi A, Kakudo K. Retinoid X receptor γ up-regulation is correlated with dedifferentiation of tumor cells and lymph node metastasis in papillary thyroid carcinoma. Pathol Int. 2011 Mar;61(3):109-15.

Chen T, Zhou G, Zhu Q, Liu X, Ha T, Kelley J, Kao R, Williams D, Li C. Over-expression of vascular endothelial growth factor 165 (VEGF165) protects the cardiomyocytes against doxorubicin-induced apoptosis. J Chemother. 2010 Dec; 22(6):402-6.

Zhang C, Li H, Wang Y, Liu W, Zhang Q, Zhang T, Zhang X, Han B, Zhou G. Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications. J Hepatol. 2010 Nov; 53(5):889-95.

Zhang Y, Wang H, Wei L, Li G, Yu J, Gao Y, Gao P, Zhang X, Wei F, Yin D, Zhou G. Transcriptional modulation of BCRP gene to reverse multidrug resistance by toremifene in breast adenocarcinoma cells. Breast Cancer Res Treat. 2010 Oct;123(3):679-89

Zhibo Gai, Gengyin Zhou, Ting Gui, Shunji Itoh, Kanta Oikawa, Kohsaku Uetani, Yasuteru Muraqaki. Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression. J Am Soc Nephrol. 2010 Sep; 21(9):1468-76.

Sun Y, Zhang T, Gao P, Meng B, Gao Y, Wang X, Zhang J, Wang H, Wu X, Zheng W, Zhou G. Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs. Breast Cancer Res Treat. 2010 Jun;121(3):591-9.

Liu Z, Liu Z, Shi Y, Zhou G. Evaluation of the immunosensitizing potential of chlorogenic acid using a popliteal lymph node assay in BALB/c mice. Food Chem Toxicol. 2010 Apr; 48(4):1059-65.

Jiang H, Fan D, Zhou G, Li X, Deng H. Phosphatidylinositol 3-kinase inhibitor (LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo. J Exp Clin Cancer Res. 2010 Apr 22; 29:34.

Wang X, Chao L, Li X, Ma G, Chen L, Zang Y, Zhou G. Elevated expression of phosphorylated c-Jun NH2-terminal kinase in basal-like and "triple-negative" breast cancers. Hum Pathol. 2010 Mar; 41(3):401-6.

Wang X, Chao L, Chen L, Ma G, Jin G, Hua M, Zhou G. The mammographic correlations with Basal-like phenotype of invasive breast cancer. Acad Radiol. 2010 Mar; 17(3):333-9.

Cai Y, Mohseny AB, Karperien M, Hogendoorn PC, Zhou G, Cleton-Jansen AM. Inactive Wnt/β-catenin pathway in conventional high-grade osteosarcoma. J Pathol. 2010 Jan;220(1):24-33.

Gai Z, Zhou G, Itoh S, Morimoto Y, Tanishima H, Hatamura I, Uetani K, Ito M, Muragaki Y. Trps1 functions downstream of Bmp7 in kidney development. J Am Soc Nephrol. 2009 Nov;20(11):2403-11.

Gao P, Zhou GY, Zhang QH, Su ZX, Zhang TG, Xiang L, Wang Y, Zhang SL, Mu K. Lymphangiogenesis in gastric carcinoma correlates with prognosis.J Pathol. 2009; 218(2):192-200.

Bai Y, Kakudo K, Nakamura M, Ozaki T, Li Y, Liu Z, Mori I, Miyauchi A, Zhou G. Loss of cellular polarity/cohesiveness in the invasive front of papillary thyroid carcinoma and periostin expression. Cancer Lett. 2009 Aug 28;281(2):188-95.

Bai Y, Zhou G, Nakamura M, Ozaki T, Mori I, Taniguchi E, Miyauchi A, Ito Y, Kakudo K. Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma. Mod Pathol. 2009 Jul;22(7):887-94.

Xiaofang Zhang, Juan Li, Zhengang Qiu, Xiaojuan Wu, Peng Gao, Gengyin Zhou. Co-suppression of  MDR1 (multidrug resistence 1) and GCS（glucosylceramide synthase）restores sensitivity to mutidrug resistance breast cancer cells by RNA interference (RNAi).Cancer bio ther, 2009; 8(12): 1-5.

Zhao M, Zhou G, Zhang Y, Chen T, Sun X, Stuart C, Hanley G, Li J, Zhang J, Yin D.beta-arrestin2 inhibits opioid-induced breast cancer cell death through Akt and caspase-8 pathways.Neoplasma. 2009; 56(2):108-13.

Li L, Mu K, Zhou G, Lan L, Auer G, Zetterberg A.Genomic instability and proliferative activity as risk factors for distant metastases in breast cancer. Br J Cancer. 2008; 99(3):513-9.

Gao P, Zhou GY, Zhang QH, Xiang L, Zhang SL, Li C, Sun YL. Clinicopathological significance of peritumoral lymphatic vessel density in gastric carcinoma. Cancer Lett. 2008 ;263(2):223-30.

Gao Y, Zhong WX, Mu DB, Yuan YP, Zhang YH, Yu JM, Sun LP, Wang L, Li YH, Zhang JB, Zhao Y, Cai SP, Zhou GY. Distributions of Angiogenesis and Lymphangiogenesis in Gastrointestinal Intramucosal Tumors. Ann Surg Oncol. 2008;15(4):1117-23.

Wei F, Wang C, Zhou G, Liu D, Zhang X, Zhao Y, Zhang Y, Yang Q. The effect of centrifugal force on the mRNA and protein levels of ATF4 in cultured human periodontal ligament fibroblast. Arch Oral Biol. 2008 Jan;53(1): 35-43.

Gao Peng, Zhou Geng-Yin, Lei Da-Peng, Zhang XF, Li Li, Xu JW, Lin XY. Selection of antisense oligonucleotides for reversal of multidrug resistance in breast carcinoma cells. Cytotherapy. 2007;11: 795-801.

Gao Peng, Zhou Geng-Yin, Guo LL, Zhang Qing-Hui, Zhen JH, Fang AJ, Lin XY. Reversal of drug resistance in breast carcinoma cells by anti-mdr1 ribozyme regulated by the tumor-specific MUC-1 promoter. Cancer Letters. 2007.10: 81-89.

Zhang C, Li H, Zhou G, Zhang Q, Zhang T, Li J, Zhang J, Hou J, Liew CT, Yin D. Transcriptional silencing of the TMS1/ASC tumor suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells. Journal of Pathology. 2007.06: 134-142.

Gao P, Zhou GY, Yin G, Liu Y, Liu ZY ,Zhang J, Hao CY. Lymphatic vessel density as a prognostic indicator for patients with stage I cervical carcinoma. Hum Pathol. 2006;37(6):719-25.

Gao P, Zhou GY, Zhang QH, Li H, Mu K, Yuan YP, Zhang J, Wang BH. Reversal MDR in breast carcinoma cells by transfection of  ribozyme designed according the secondary structure of mdr1 mRNA. Chinese Journal of Physiology . 2006, 49(2):96-103.

Zhang YH, Zhou GY, Wang HP, Zhang XF, Wei FL, Cai YP, Yin DL. Transcriptional upregulation of breast cancer resistance protein by 17β-estradiol in ERα-positive MCF-7 breast cancer cells. Oncology, 2006; 71(5-6):446-55.

Han Bo, Nakamura M, Zhou Geng-yin, Ishii A, Nakamura A, Bai Y, Mori I, Kakudo K. Calcitonin inhibits invasion of breast cancer cells: involvement of urokinase-type plasminogen activator (uPA)  and uPA receptor. Int J Oncol. 2006 Apr;28(4):807-14.

Sun YL, Zhou GY, Li KN, Gao P, Zhang QH, Zhen JH., Bai YH., Zhang XF. Suppression of glucosylceramide synthase by RNA interference reverses multidrug resistance in human breast cancer cells. Neoplasma, 2006, 53(1):1-8.

Li WT, Zhou GY,Wang CL, Guo CH, Song XR, Chi WL. Modulation of breast cancer resistance protein mediated atypical multidrug resistance using RNA interference delivered by adenovirus. Chin Med J (Engl). 2005; 118(13): 1123-1126.

Li WT, Zhou GY, Song XR, Chi WL, Ren RM, Wang XW. Modulation of BCRP mediated atypical multidrug resistance phenotype by RNA interference. Neoplasma. 2005;52 (3) :219-224.
  

1.Pathology. Science and Medicine Publishing House. 2006.03. Chief Editor.

2.Techniques of Histopathology. Peking  University Medicine Press. 2006.06. Chief Editor.

3. Pathology and Clinic of thyroid. People’s Medical Publishing House. 2005.01. Chief Editor.

4. Pathology . High Educational Publishing House. 2008.01, Deputy Chief Editor.

5. Pathology. People’s Medical Publishing House. 2005.08. Editor.

6. Diagnostic HistoPathology of Tumor. Shandong Science and Technology Press. 2001.12. Primary Translator.

7. Diagnostic Atlas of Renal Pathology. Peking university medical Press.2007.01
Primary Translator.
 

 
1.National Nature Science Grand (2012-2015)

2.Special Grant of Ministry of Education for PhDs in Universities(2002-2004)

3.Shandong Science Grant (2003-2005)

4.Shandong Science Grant (2002 -2004)

5.Shandong Scientific Improvement Grant (2005-2007)

6.Shandong Health Grant (2001-2004)

 

My research is mainly focused on multidrug resistance, one direction is to   reverse multi-drug resistance in tumors, especially in breast carcinoma. We applied different methods to reverse the phenomenon, such as the extraction of grape seed, reverse oligonucleotide and RNAi techniques; the other one is to study the mechanism of production and regulation of multi-drug resistance.  I am also interested in methylation of DNA and its influence to MDR, hypoxia and its influence to MDR. In addition, I carry on diagnosis in clinic and my favorite field is renal disease and lymphoma.