He was host of national key clinical specialist project, and director of pathology department of shandong university medical school, director of pathology department of shandong university qilu hospital and director of pathology department of shandong university second hospital.

Academic expertise: more than 30 years of medical experience, with high attainments in the field of pathological diagnosis, especially in the diagnosis of gynecological pathology, and his main research direction is the pathogenesis and diagnostic technology of gynecological tumors. He was a postdoctoral fellow at Massachusetts general hospital, harvard medical school, from 2002 to 2004.

Academic tenure: the pathology branch in shandong province medical association, director of the committee member, shandong lung cancer alliance vice chairman, pathology branch of Chinese medical association member, Chinese medical association branch of pathology of female reproductive committee member, deputy team leader, the Chinese medical association branch of obstetrics and gynecology pathology group committee deputy head of department of gynaecology, colposcopy and cervical pathology to China healthy birth science association standing committee, the national center for telemedicine and Internet medicine pathology expert committee standing committee and director of organization library working group in shandong province.Editorial board, Chinese journal of pathology, journal of clinical and experimental pathology, medical edition of journal of shandong university.

Academic achievements: presided over one major project of the national health and family planning commission, one national natural fund, three provincial science and technology public relations projects, and participated in more than 10 national natural fund and provincial project. A total of 34 SCI papers were published, 19 SCI papers were published by the first author and corresponding author, and 16 papers were published by Chinese core journals. It has trained 23 master students and 7 doctoral students.

 

1)Ta-Chiang Liu, Tingguo Zhang, Hiroshi Fukuhara, Toshihiko Kuroda, Tomoki Todo, Robert L Martuza, Samuel D Rabkin, Andreas Kurtz. Oncolytic HSV armed with platelet factor 4, an antiangiogenic agent, shows enhanced efficacy. Molecular therapy, 2007; 14(6):789-97.

2)Nisreen Abushahin, Tingguo Zhang, Sarah Chiang, Xiangsheng Zhang, Kenneth Hatch, Wenxin Zheng. Serous endometrial intraepithelial carcinoma arising in adenomyosis: a report of 5 cases. International journal of gynecological pathology : 2011; 30(3):271-81.

3) Li Li, Jinsong Li, Chunyan Hao, Cuijuan Zhang, Kun Mu, Yan Wang, Tingguo Zhang. Immunohistochemical evaluation of solid pseudopapillary tumors of the pancreas: the expression pattern of CD99 is highly unique. Cancer letters. 2011; 310(1):9-14.

4) Shuo Liang1, Kun Mu1,2, Yan Wang1,2, Zhiqiang Zhou1,2, Juan Zhang2, Yan Sheng1 and Tingguo Zhang1,2*  CyclinD1, a prominent prognostic marker for
endometrial diseases. Diagnostic Pathology 2013, 8:138

5) Haiyan Chen1, 2, #, Tingguo Zhang1, #, Yan Sheng1, #, Cheng Zhang1, Yunfei Peng1, Xiao Wang1, Cuijuan Zhang，Methylation Profiling of Multiple Tumor Suppressor Genes in Hepatocellular Carcinoma and the Epigenetic Mechanism of 3OST2 Regulation.Journal of cancer 2015; 6(8): 740-749. doi: 10.7150/jca.11691

6) Haiyan Chen1,2*, Cuijuan Zhang1*, Yan Sheng1, Shuzhe Yao1, Zhiyan Liu1, Cheng Zhang1, Tingguo Zhang, Frequent SOCS3 and 3OST2 promoter methylation and their epigenetic regulation in endometrial carcinoma. Am J Cancer Res 2015;5(1):180-190

7) Juan Li a, b, Jing Wang b, Ming Li c, Linlin Yin d, Xiang-An Li e,∗, Ting-Guo Zhang a,∗ Up-regulated expression of scavenger receptor class B type 1 (SR-B1) is associated with malignant behaviors and poor prognosis of breast cancer. Pathology – Research and Practice 212 (2016) 555–559

8) Yu N , Zhang T , Zhao D , Cao Z , Du J , Zhang Q . CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation, invasion and apoptosis. Pathol Res Pract 2018 Feb;214 (2): 233-239

9) Sheng Y¹, Wang H², Liu D³, Zhang C³, Deng Y³, Yang F³, Zhang T⁴, Zhang C^5. Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma. Gynecol Oncol. 2016 Jan;140(1):145-51.

10) Li C¹, Zhang T. Human mammaglobin: A specific marker for breast cancer prognosis.  J BUON. 2016 Jan-Feb;21(1):35-41.

11) Xu Y¹, Li X², Wang H³, Xie P⁴, Yan X⁴, Bai Y⁴, Zhang T¹. Hypermethylation of CDH13, DKK3 and FOXL2 promoters and the expression of EZH2 in ovary granulosa cell tumors. Mol Med Rep. 2016 Sep;14(3):2739-45.

12) Lang Z¹, Wu Y, Pan X, Qu G, Zhang T. Study of differential gene expression between invasive multifocal/ multicentric and unifocal breast cancer. J BUON. 2018 Jan-Feb;23(1):134-142.

13) Wang W^1,2, Yang Y³, Chen X^4,5, Shao S², Hu S², Zhang T^6,7.MAGI1 mediates tumor metastasis through c-Myb/miR-520h/MAGI1 signaling pathway in renal cell carcinoma. Apoptosis. 2019 Jul 27. doi: 10.1007/s10495-019-01562-8.

14) Deng Y^1,2, Han Q³, Mei S¹, Li H¹, Yang F^1,4, Wang J¹, Ge S¹, Jing X¹, Xu H¹, Zhang T¹.Cyclin-dependent kinase subunit 2 overexpression promotes tumor progression and predicts poor prognosis in uterine leiomyosarcoma. Oncol Lett. 2019 Sep;18(3):2845-2852.

15) Yang Y^1,2, Wang W³, Chang H⁴, Han Z², Yu X⁵, Zhang T^1,6.Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells. J Cell Mol Med. 2019 Sep 10. doi: 10.1111/jcmm.14592. [Epub ahead of print]